Invitrogen

HSP90 beta Monoclonal Antibody (MBH90B)

3 Published Figures
4 References
View all (40) HSP90 beta antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA1-10373

Applications
Tested Dilution
Publications

Western Blot (WB)

1 µg/mL
View 4 publications 4 publications

Immunocytochemistry (ICC/IF)

1 µg/mL
-

Immunoprecipitation (IP)

1 µg/mL
-
Product Specifications

Species Reactivity

Bovine, Human, Mouse

Published species

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

MBH90B

Immunogen

Peptide corresponding to the EEVHHGEEEVEC sequence within N-terminal part of human Hsp90 (aa 3-14).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4, with 0.2% BSA

Contains

15mM sodium azide

Storage conditions

4°C, do not freeze

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11153425

Product Specific Information

This antibody recognizes the EEVHHG epitope within the N-terminal part of Hsp90 beta an ubiquitously expressed intracellular protein with calculated Mw of 83.3 kDa, however, migrating as a 90 kDa band under reducing SDS-PAGE conditions.

Target Information

Heat shock proteins (HSP) are expressed in response to various biological stresses, including heat. HSP90 is a 90 kDa protein that is induced under stress conditions, but is also one of the most abundant cellular proteins found under non-stress conditions. HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. HSP90 has been found to be associated with a number of other intracellular proteins, including steroid receptors, actin, tubulin, aryl hydrocarbon (Ah) receptor, and some kinases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Heat shock 84 kDa; heat shock 90 kDa protein; heat shock 90kD protein 1, beta; heat shock 90kDa protein 1, beta; Heat shock protein; heat shock protein 1, beta; heat shock protein 90 kDa; heat shock protein 90kDa alpha (cytosolic), class B member 1; heat shock protein 90kDa alpha family class B member 1; Heat shock protein family C member 3; Heat shock protein HSP 90-beta; heat shock protein, 84 kDa 1; HSP; HSP 84; HSP 90; HSP90-beta; retinal degeneration slow protein; RP1-302G2.1; TSTA; Tumor-specific transplantation 84 kDa antigen

View more View less

Gene Aliases: 90kDa; AL022974; C81438; D6S182; HSP84; Hsp84-1; Hsp90; HSP90AB1; HSP90B; HSPC2; HSPC3; HSPCB

View more View less

UniProt ID: (Bovine) Q76LV1, (Human) P08238, (Mouse) P11499

View more View less

Entrez Gene ID: (Bovine) 767874, (Human) 3326, (Mouse) 15516

View more View less

Function(s)
double-stranded RNA binding protein kinase regulator activity protein kinase binding heat shock protein binding ubiquitin protein ligase binding peptide binding protein homodimerization activity histone deacetylase binding ATP-dependent protein binding protein binding involved in protein folding protein dimerization activity tau protein binding DNA polymerase binding histone methyltransferase binding UTP binding CTP binding protein binding ATP binding GTP binding sulfonylurea receptor binding kinase binding MHC class II protein complex binding nitric-oxide synthase regulator activity TPR domain binding dATP binding ion channel binding poly(A) RNA binding unfolded protein binding cadherin binding involved in cell-cell adhesion nucleotide binding Hsp90 family chaperone
Process(es)
placenta development telomere maintenance via telomerase virion attachment to host cell central nervous system neuron axonogenesis establishment of cell polarity positive regulation of transforming growth factor beta receptor signaling pathway regulation of protein ubiquitination negative regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of phosphoprotein phosphatase activity positive regulation of peptidyl-serine phosphorylation negative regulation of apoptotic process positive regulation of cell differentiation axon extension chaperone-mediated protein complex assembly positive regulation of protein kinase B signaling positive regulation of telomerase activity regulation of interferon-gamma-mediated signaling pathway regulation of type I interferon-mediated signaling pathway negative regulation of cell cycle arrest cellular response to interleukin-4 fibril organization negative regulation of transforming growth factor beta activation positive regulation of cyclin-dependent protein kinase activity telomerase holoenzyme complex assembly positive regulation of protein localization to cell surface protein folding response to unfolded protein response to salt stress positive regulation of protein binding positive regulation of protein import into nucleus, translocation Fc-gamma receptor signaling pathway involved in phagocytosis negative regulation of neuron apoptotic process positive regulation of nitric oxide biosynthetic process positive regulation of cell size protein stabilization cellular response to organic cyclic compound positive regulation of protein serine/threonine kinase activity cell-cell adhesion regulation of cellular response to heat response to stress
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support