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This intronless gene encodes a 70 kDa heat shock protein which is a member of the heat shock protein 70 family. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.
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Protein Aliases: 70 kda heat shock protein-2; chaperone; heat shock 70 kD protein 1; heat shock 70 kD protein 2; Heat shock 70 kDa protein 1; Heat shock 70 kDa protein 1A; Heat shock 70 kDa protein 1B; Heat shock 70 kDa protein 2; heat shock 70kDa protein 1A; heat shock 70kDa protein 1B; Heat shock protein; Heat Shock Protein 70; heat-shock 70-kilodalton protein 1A; heat-shock 70-kilodalton protein 1B; HSP; HSP70-1A; HSP70.1; HSP70.2; HSP70I
Gene Aliases: HSP70; HSP70-1; HSP70-2; HSPA1; HSPA1A; HSPA1B; HSPA2
UniProt ID: (Bovine) Q27975
Entrez Gene ID: (Bovine) 282254
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