MA5-15578 targets HSP70 in IF, IHC, and WB applications and shows reactivity with Human samples.
The MA5-15578 immunogen is purified recombinant fragment of human HSP70 expressed in E. Coli.
MA5-15578 detects HSP70 which has a predicted molecular weight of approximately 70kDa.
This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.
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Protein Aliases: 110 kDa; APG-2; epididymis secretory sperm binding protein Li 5a; Heat shock 70 kDa protein 4; Heat shock 70-related protein APG-2; heat shock 70kD protein 4; heat shock 70kDa protein 4; heat shock protein; heat shock protein, 110 kDa; HS24/P52; hsp70; hsp70 RY; HSP70RY; HSPH2; RY
Gene Aliases: 70kDa; AI317151; APG-2; APG2; HEL-S-5a; HS24/P52; Hsp110; hsp70; Hsp70RY; HSPA4; HSPH2; mKIAA4025; RY
UniProt ID: (Human) P34932