Immunogen sequence: LQQPAIFCNM VFDWPARHWN AKYLSQVLHG KQIRFRMGMK SMSTVPQFET TCNYVEATLE EFLTWNCDQS SISGPFRDYD HSKFWAYADY KYFVSLFEDK TDLFQDVKWS DFGFPGRNGQ ESTLWIGSLG AHTPCHLDSY GCNLVFQ
HSPBAP1 (HSPB (heat shock 27kDa) associated protein 1), also known as PASS1 (protein associated with small stress protein 1), is a 488 amino acid cytoplasmic protein that contains one JMJC (Jumonji C) domain and shares 80% identity with its rat homolog, PASS1. Widely expressed with highest expression in ovary, thymus and pancreas, HSPBAP1 is thought to play a role in mediating cellular stress responses within the cell. Due to the presence of a JMJC domain, HSPBAP1 may be involved in chromatin remodeling events. Defects or translocations in the gene encoding HSPBAP1 are associated with renal cell carcinoma 1 (RCC1), suggesting a possible role for HSPBAP1 in carcinogenesis. Three isoforms of HSPBAP1 exist due to alternative splicing events.
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Protein Aliases: 27 kDa heat shock protein-associated protein 1; FLJ22623; FLJ39386; Heat shock protein; HSP; HSP27; HSP28; HSPB (heat shock 27kDa) associated protein 1; HSPB1-associated protein 1; Protein associated with small stress protein 1; protein associating with small stress protein PASS1
Gene Aliases: HSPBAP1; PASS1
UniProt ID: (Human) Q96EW2
Entrez Gene ID: (Human) 79663