This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: TIKSLQKEAT LCVSDLGTRA KLASFSFLPQ SSLSSEKLFQ RSIHREPGSY TGRRTMQSIS NEQ
Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 97%.
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5- dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 5-HT-2; 5-HT-2A; 5-HT2 receptor; 5-HT2A; 5-HT2a receptor; 5-HT2A/2C; 5-HT2A/2C receptor; 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled; 5-hydroxytryptamine receptor 2A; 5HT2A Receptor; HTR2; HTR2A; Serotonin 2a receptor; Serotonin 5-HT-2A receptor; Serotonin receptor 2A
Gene Aliases: 5-HT2A; HTR2; HTR2A
UniProt ID: (Human) P28223
Entrez Gene ID: (Human) 3356