Invitrogen

HTR2A Polyclonal Antibody

Advanced Verification

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details

View all (7) HTR2A antibodies

Datasheet

Datasheet

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HTR2A Antibody in Immunohistochemistry (IHC) — Immunohistochemical staining of HTR2A in human cerebral cortex and pancreas tissues using HTR2A Polyclonal Antibody (Product # PA5-53111). Corresponding HTR2A RNA-seq data are presented for the same tissues.

HTR2A Antibody in Relative expression — Relative expression in different tissues in IHC: Detection of differential expression levels of HTR2A demonstrates antibody specificity. Immunohistochemical analysis of HTR2A using anti-HTR2A Polyclonal Antibody (Product # PA5-53111), shows significant staining of HTR2A in human cerebral cortex and shows minimal or weak staining in human pancreas tissues. The relative expression levels of HTR2A within each tissue is shown using RNA-Seq. {RE}

Product Details

Tested Applications

Dilution

Immunohistochemistry (IHC)

1:50-1:200

Product Specifications

Species Reactivity

Human

Host / Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human HTR2A

Conjugate

Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

RRID

AB_2642584

Product Specific Information

Immunogen sequence: TIKSLQKEAT LCVSDLGTRA KLASFSFLPQ SSLSSEKLFQ RSIHREPGSY TGRRTMQSIS NEQ

Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 97%.

Target Information

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5- dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: 5-HT-2; 5-HT-2A; 5-HT2 receptor; 5-HT2A; 5-HT2a receptor; 5-HT2A/2C; 5-HT2A/2C receptor; 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled; 5-hydroxytryptamine receptor 2A; 5HT2A Receptor; HTR2; HTR2A; Serotonin 2a receptor; Serotonin 5-HT-2A receptor; Serotonin receptor 2A

Gene Aliases: 5-HT2A; HTR2; HTR2A

UniProt ID: (Human) P28223

Entrez Gene ID: (Human) 3356

Molecular Function: G-protein coupled receptor receptor