The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit B of the type 3 receptor for 5-hydroxytryptamine, a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude.
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Protein Aliases: 5-HT3-B; 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic; 5-hydroxytryptamine 3 receptor B subunit; 5-hydroxytryptamine receptor 3B; Serotonin receptor 3B; serotonin-gated ion channel subunit
Gene Aliases: 5-HT3B; HTR3B
UniProt ID: (Human) O95264
Entrez Gene ID: (Human) 9177
Molecular Function: ligand-gated ion channel