Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
HYB 130-11-02 detects Tetranectin in human samples.
HYB 130-11-02 has been successfully used in ELISA, Western Blot and Immunohistochemistry procedures. HYB 130-11-02 reacts poorly with tetranectin in sandwich ELISA in combination with a polyclonal antibody against tetranectin. By Western blot, this antibody reacts strongly with TN monomer. Especially good as detecting antibody. Strong recognition of Tetranectin in Immunohistochemistry on both fresh frozen and paraffin-embedded tissues.
HYB 130-11-02 immunogen is a Tetranectin protein purified from human citrate plasma and coupled to PPD.
Epitope specificity is shared by HYB 130-13-02, as determined by inhibition ELISA.
NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL
Tetranectin (TN) is a serum and tissue protein, a C-type lectin, which binds to Ca++. It is a homotrimer of monomers each with a mass of 20 kDa, plasma or serum concentrations of TN are found to be approximately 10 mg/l. In vitro, TN can bind to kringle 4 of plasminogen and enhance the activation of plaminogen to plasmin, catalyzed by tissue plasminogen activator in the presence of poly-D-lysine. TN is best known as a prognostic marker in ovarian cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C-type lectin domain family 3 member B; C-type lectin domain family 3, member B; Plasminogen kringle 4-binding protein; Tetranectin; tetranectin (plasminogen-binding protein); TN
Gene Aliases: CLEC3B; TNA
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