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Bioss

Heme Oxygenase 1, Heme Oxygenase 2 Polyclonal Antibody

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Product Details

BS-2075R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300
-

Immunohistochemistry (Paraffin) (IHC (P))

1:500
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Chicken, Human, Mouse, Pig, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human Heme Oxygenase 1.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Heme oxygenase cleaves the heme ring at the alpha methane bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: heat shock protein 32; heat shock protein, 32-kD; heme oxygenase; heme oxygenase (decycling) 1; heme oxygenase (decycling) 2; heme oxygenase (decyclizing) 1; heme oxygenase-2 (EC 1.14.99.3); hemoxygenase; HMOX1; HMOX2; HO-1; HO2; P32 protein; unnamed protein product

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Gene Aliases: bK286B10; D8Wsu38e; Hemox; Heox; HEOXG; Hmox; HMOX1D; HO-1; HO-2; HO1; HO2; HSP32

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UniProt ID: (Pig) P32394, (Human) P09601, (Chicken) P14791, (Human) P30519, (Rat) P06762, (Mouse) P14901, (Mouse) O70252, (Rat) P23711

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Entrez Gene ID: (Pig) 445512, (Human) 3162, (Chicken) 396287, (Chicken) 416663, (Human) 3163, (Pig) 396622, (Rat) 24451, (Mouse) 15368, (Mouse) 15369, (Rat) 79239

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Function(s)
heme oxygenase (decyclizing) activity heme binding identical protein binding protein homodimerization activity metal ion binding structural molecule activity protein binding enzyme binding phospholipase D activity arachidonic acid omega-hydroxylase activity oxygenase
Process(es)
wound healing involved in inflammatory response heme oxidation cellular iron ion homeostasis apoptotic process response to oxidative stress erythrocyte homeostasis regulation of transcription from RNA polymerase II promoter in response to iron response to nicotine heme catabolic process heme metabolic process positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation by host of viral transcription positive regulation of smooth muscle cell proliferation negative regulation of smooth muscle cell proliferation iron ion homeostasis cellular response to arsenic-containing substance cellular response to cadmium ion negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of viral life cycle angiogenesis endothelial cell proliferation negative regulation of leukocyte migration regulation of transcription from RNA polymerase II promoter smooth muscle hyperplasia positive regulation of chemokine production low-density lipoprotein particle clearance cellular response to heat intracellular signal transduction response to hydrogen peroxide regulation of angiogenesis positive regulation of angiogenesis multicellular organismal iron ion homeostasis positive regulation of cell migration involved in sprouting angiogenesis negative regulation of ferroptosis negative regulation of cytokine production involved in inflammatory response positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis response to hypoxia phospholipid metabolic process small GTPase mediated signal transduction regulation of blood pressure negative regulation of cell proliferation intrinsic apoptotic signaling pathway in response to DNA damage response to xenobiotic stimulus negative regulation of muscle cell apoptotic process positive regulation of macroautophagy negative regulation of macroautophagy cellular response to nutrient negative regulation of mast cell cytokine production positive regulation of apoptotic process negative regulation of mast cell degranulation negative regulation of neuron apoptotic process response to estrogen cellular response to cisplatin liver regeneration negative regulation of epithelial cell apoptotic process response to arachidonate response to 3-methylcholanthrene negative regulation of vascular smooth muscle cell proliferation cellular response to iron ion starvation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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