|Tested species reactivity||Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues 100-200 of mouse TIM-3.|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1-3 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Suggested positive control: mouse and rat kidney protein or cell lysate.
Principal Names: TIMD3; FLJ14428; T-cell immunoglobin mucin 3(TIM3); Kidney-injury molecule 3(KIM3); Hepatitis A viral cellular receptor 2(HAVCR2); Official Gene Symbol- HAVCR2 Gene ID- 84868(Human) Gene Map Locus- 5q33.3(Human) HAVCR2 is a 281 A.A Type-1 Th1- specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells. It consists of an IgV-region like domain and a mucin-like domain in the extracellular region and a conserved Tyrosine phosphorylation motif in the cytoplasmic region. HAVCR2 regulates macrophage activation thereby down regulating aggressive Th-1 mediated immune responses and facilitates in the development of immune tolerance. It plays an important role in the induction of autoimmune diseases by regulating macrophage activation. Pathological significance of HAVCR2 has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th-1 dependent autoimmune disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.