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|Tested species reactivity||Virus|
|Published species reactivity||Virus|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Hepatitis B virus|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:200|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 3 publications below|
PA5-16368 targets Hepatitis B Virus Core Antigen in IHC (P) applications and shows reactivity with Human samples.
The PA5-16368 immunogen is hepatitis B virus.
Hepatitis B virus is spherical in shape with a diameter of 42nm. It contains a 27 nm partially double stranded DNA core enclosed within a lipoprotein coat. The antigenic activity of the nucleocapsid core is designated as hepatitis B core antigen. The antigens in the outer surface are called as hepatitis B virus surface antigens. Core antigens are localized within the nuclei whereas the surface antigens are present in the cytoplasm of the infected cells. Antibodies to surface antigens appear in circulation at an early stage of infection whereas the antibodies to the core antigens are detected after several weeks.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Clinical significance of serum HBsAg levels and association with liver histology in HBeAg positive chronic hepatitis B.
PA5-16368 was used in immunohistochemistry to study 198 HBeAg-positive chronic HBV patients to determine the clinical significance of the relationship between HBsAg levels and hepatic histology
|Cheng PN,Tsai HW,Chiu YC,Ho CH,Wu IC,Chang TT||Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology (57:323)||2013|
Biological characteristics of the rtA181T/sW172* mutant strain of Hepatitis B virus in animal model.
PA5-16368 was used in immunohistochemistry to use murine models to study the biochemistry of the HBV rtA181/sW172* mutant strain
|Dai J,Chen EQ,Bai L,Gong DY,Zhou QL,Cheng X,Huang FJ,Tang H||Virology journal (9:null)||2012|
Inhibition of hepatitis B Virus replication by hepatocyte nuclear factor 4-alpha specific short hairpin RNA.
PA5-16368 was used in immunohistochemistry to study the ability of shRNA-mediated knockdown of HNF4-alpha to impair the replication of HBV in a murine model
|He F,Chen EQ,Liu L,Zhou TY,Liu C,Cheng X,Liu FJ,Tang H||Liver international : official journal of the International Association for the Study of the Liver (32:742)||2012|
Hepatitis B virus nucleocapsid particles; HepB