HAMP is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity.
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Protein Aliases: Hepc20; Hepc25; Hepcidin; Hepcidin-20; Hepcidin-25; LEAP-1; Liver-expressed antimicrobial peptide 1; PLTR; Putative liver tumor regressor
Gene Aliases: HAMP; HEPC; HFE2B; LEAP1; PLTR; UNQ487/PRO1003
UniProt ID: (Human) P81172
Entrez Gene ID: (Human) 57817