|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide: Y(68) I V H L G Q H N L Q K E E G(82)|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-4312 detects the Hippostatin/KLK11 protein in human, mouse, and rat samples.
PA1-4312 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~38 kDa protein representing KLK11 in LNCaP cell lysate.
PA1-4312 immunizing peptide corresponds to amino acid residues 68-82 of the 35 kDa human hippostasin/KLK11protein. There is 86% sequence identity to mouse and rat.
Hippostasin, also known as KLK11, is a kallikrein-like serine protease, which has two alternatively spliced isoforms, brain-type and prostate-type. Hippostasin plays a role in the prostate, including reproductive and/or tumorigenic functions. Elevated serum levels of KLK11 were found in 70% of women with ovarian cancer and in 60% of men with prostate cancer. Analysis of the KLK11 biomarker in serum may aid in the diagnosis and monitoring of ovarian and prostatic carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.