Since it is highly conserved across species, the antibody may react with many other species.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Histone octamers are an essential component of the nucleosomal complex with key roles in chromatin packaging and target gene transcription. They undergo various post-translational modifications including methylation, acetylation and phosphorylation to facilitate chromatin regulation. Modified histones display varied distribution patterns at the heterochromatin and the euchromatin, hence defining actively transcribed or repressed genes in the eurochromatin and the 'silenced' loci in the heterochromatin. These modifications in turn serve as epigenetic markers for transcriptional status of a gene and landing sites for transcriptional complexes, fundamental to understanding several biological processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: H3 histone family, member A; H3/A; H3FA; histone 1, H3a; histone H3/a
Gene Aliases: H3/A; H3FA
Entrez Gene ID: (Human) 8350