|Tested species reactivity||Human, Mouse|
|Published species reactivity||Not Applicable|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant protein fragment corresponding to a region within amino acids 470 and 635 of Human Hsc70|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:1000-1:10,000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 1 publications below|
PA5-27337 targets Hsc70 in IF, IHC (P), and WB applications and shows reactivity with Human and mouse samples.
The PA5-27337 immunogen is recombinant protein fragment corresponding to a region within amino acids 470 and 635 of Human Hsc70.
The product encoded by this gene belongs to the heat shock protein 70 family which contains both heat-inducible and constitutively expressed members. The latter are called heat-shock cognate proteins. This gene encodes a heat-shock cognate protein. This protein binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Two alternatively spliced variants have been characterized to date.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
A Non-enveloped Virus Hijacks Host Disaggregation Machinery to Translocate across the Endoplasmic Reticulum Membrane.
PA5-27337 was used in western blot to discover that Hsp105 cooperates with Hsc70 to facilitate virus entry
|Ravindran MS,Bagchi P,Inoue T,Tsai B||PLoS pathogens (11:null)||2015|