|Tested species reactivity||Human|
|Published species reactivity||Bacteria|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 381-412 amino acids from the C-terminal region of human HtrA1|
|Purification||Size-exclusion - Dialysis, Ammonium sulfate precipitation|
|Contains||0.09% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:100|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 1 publications below|
This antibody is predicted to react with rat based on sequence homology.
HtrA1 is a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Lyme disease spirochaetes possess an aggrecan-binding protease with aggrecanase activity.
PA5-11413 was used in western blot to study a novel aggrecanase produced by the Lyme disease spirochaete during human infection and the pathogenic significance
|Russell TM,Johnson BJ||Molecular microbiology (90:228)||2013|