PEP-056 is a 21 amino acid synthetic peptide whose sequence corresponds to residues 758-777 of human Dyn2. The sequence of this peptide is (amino to carboxy terminus): (C) S758-H-S-P-T-P-Q-R-R-P-V-S-S-I-H-P-P-G-R-P777 (The N-terminal cysteine has been added to facilitate conjugation and is not a part of the native human Dyn2 sequence).
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and Dyn2, catalog # PA1-661. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.
Reconstitute with 0.1 mL of distilled water.
Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: dynamin II; Dynamin-2
Gene Aliases: CMT2M; CMTDI1; CMTDIB; DI-CMTB; DNM2; DYN2; DYNII; LCCS5
UniProt ID: (Human) P50570
Entrez Gene ID: (Human) 1785