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|Tested species reactivity||Human|
|Published species reactivity||Mouse, Human|
|Host / Isotype||Mouse / IgG2b|
|Immunogen||Activated human peripheral blood mononuclear cells|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
|Immunohistochemistry (Frozen) (IHC (F))||2-4 µg/ml|
|Western Blot (WB)||1:100-1:10,000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-11966 targets Human MHC II (HLA-DR) in FACS, WB and IHC (F) applications and shows reactivity with Human samples. This antibody does not react with mouse tissue in Western blot applications.
The MA5-11966 immunogen is activated human peripheral blood mononuclear cells.
HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of an alpha chain (36 kDa) and a beta chain (27 kDa). It is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells. They therefore have a critical role in the initiation of the immune response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Amyloid-β oligomers stimulate microglia through a tyrosine kinase dependent mechanism.
MA5-11966 was used in immunohistochemistry to study the role of tyrosine kinase activity in the stimulation of microglia by oligomers of beta-amyloid
|Dhawan G,Floden AM,Combs CK||Neurobiology of aging (33:2247)||2012|
Alzheimer's disease modifies progenitor cell expression of monoamine oxidase B in the subventricular zone.
MA5-11966 was used in immunohistochemistry to study the effect of Alzheimer's disease on the expression of progenitor cell monoamine oxidase B
|Pugliese M,Rodríguez MJ,Gimeno-Bayon J,Pujadas L,Billett EE,Wells C,Mahy N||Journal of neuroscience research (88:2588)||2010|
Combined therapy of transcatheter hepatic arterial embolization with intratumoral dendritic cell infusion for hepatocellular carcinoma: clinical safety.
MA5-11966 was used in immunohistochemistry to study the use of transcatheter hepatic arterial embolization with intratumoral dendritic cell infusion for hepatocellular carcinoma
|Nakamoto Y,Mizukoshi E,Tsuji H,Sakai Y,Kitahara M,Arai K,Yamashita T,Yokoyama K,Mukaida N,Matsushima K,Matsui O,Kaneko S||Clinical and experimental immunology (147:296)||2007|
Immunohistochemical analysis of orbital connective tissue specimens of patients with active Graves ophthalmopathy.
MA5-11966 was used in immunohistochemistry to study the cells infiltrating orbital connective tissue in patients with active Graves opthalmopathy
|Avunduk AM,Avunduk MC,Pazarli H,Oguz V,Varnell ED,Kaufman HE,Aksoy F||Current eye research (30:631)||2005|
Phase I study of autologous tumor vaccines transduced with the GM-CSF gene in four patients with stage IV renal cell cancer in Japan: clinical and immunological findings.
MA5-11966 was used in immunohistochemistry to evaluate specific tumor vaccines against stage IV renal cell cancer
|Tani K,Azuma M,Nakazaki Y,Oyaizu N,Hase H,Ohata J,Takahashi K,OiwaMonna M,Hanazawa K,Wakumoto Y,Kawai K,Noguchi M,Soda Y,Kunisaki R,Watari K,Takahashi S,Machida U,Satoh N,Tojo A,Maekawa T,Eriguchi M,Tomikawa S,Tahara H,Inoue Y,Yoshikawa H,Yamada Y,Iwamoto A,Hamada H,Yamashita N,Okumura K,Kakizoe T,Akaza H,Fujime M,Clift S,Ando D,Mulligan R,Asano S||Molecular therapy : the journal of the American Society of Gene Therapy (10:799)||2004|
Identification of new MHC-restriction elements for presentation of the p210(BCR-ABL) fusion region to human cytotoxic T lymphocytes.
MA5-11966 was used in blocking or activating experiment to investigate the immune response against the p210(BCR-ABL) fusion region in chronic myelogenous leukemia
|Sun JY,Senitzer D,Forman SJ,Chatterjee S,Wong KK||Cancer immunology, immunotherapy : CII (52:761)||2003|
DR alpha chain; histocompatibility antigen HLA-DR alpha; HLA class II histocompatibility antigen; MHC cell surface glycoprotein; MHC class II antigen DRA
HLA-DRA; HLA-DRA1; MLRW