|Control (Ctrl)||Assay dependent|
|Host / Isotype||E.coli|
|Storage buffer||25mM tris HCl, pH 8.0, with 50% glycerol, 1mM DTT, 2mM EDTA, 0.01M L-glutathione, 0.05% Tween 20, 75mM NaCl|
Tyrosine-protein phosphatase, non-receptor type 1 (PTP1B) also know as Protein-tyrosine phosphatase 1B, PTPN1 is a PTP (protein tyrosine phosphatase) first isolated from human placenta. The protein is unrelated to other known phosphatases but is similar to common leukocyte antigen (CD45) and to LAR a homolog of the neural adhesion molecule NCAM. PTP1B negatively regulates insulin sensitivity by dephosphorylating the insulin receptor. Akt is a ser/thr kinase effector of insulin signaling that phosphorylates substrates at the consensus motif RXRXXS/T. PTP1B contains the Akt phosphorylation motif (RYRDVS50), and PTP1B (but not mutants with substitutions for Ser50) are phosphorylated by Akt. Insulin stimulation also causes a significant increase in phosphorylation of PTP1B.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: protein tyrosine phosphatase, placental; Protein-tyrosine phosphatase 1B; PTP-1B; PTPN1; Tyrosine-protein phosphatase non-receptor type 1
Gene Aliases: PTP1B; PTPN1
UniProt ID: (Human) P18031
Entrez Gene ID: (Human) 5770
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.