This peptide corresponds to 18 amino acids near the carboxy terminus of human SH3BP4.
PEP-0861 can be used as a blocking peptide with polyclonal antibody PA5-20747.
SH3BP4 was initially isolated as a novel cDNA using differential display analysis using cultured human corneal fibroblasts. The protein contains three Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site. SH3BP4 has been shown to interact with specific endocytic proteins such as clathrin, dynamin, and the transferrin receptor (TfR) and localizes to TfR-containing coated pits and vesicles. It is thought to be involved in cargo-specific control of clathrin-mediated endocytosis, specifically controlling the internalization of TfR. At least two isoforms of SH3BP4 are known to exist.
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Protein Aliases: EH-binding protein 10; SH3 domain-binding protein 4; SH3-domain binding protein 4; Transferrin receptor-trafficking protein
Gene Aliases: BOG25; EHB10; SH3BP4; TTP
UniProt ID: (Human) Q9P0V3
Entrez Gene ID: (Human) 23677