PEP-286 is a 17 amino acid synthetic peptide whose sequence is derived from human SNX1 protein. The sequence of this peptide is (amino to carboxy terminus): Q (139)-E-D-Q-F-D-L-T-V-G-I-T-D-P-E-K-I (155)
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product, SNX1, catalog # PA1-836. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.
Reconstitute with 0.1 mL of distilled water.
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with family members. This gene results in three transcript variants encoding distinct isoforms.
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Protein Aliases: MGC8664; SNX1A; sorting nexin 1A; Sorting nexin-1
Gene Aliases: HsT17379; SNX1; VPS5
UniProt ID: (Human) Q13596
Entrez Gene ID: (Human) 6642