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Product Details
MA5-17767
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
7-16.17
Immunogen
B10.p
Conjugate
Form
Liquid
Concentration
0.7 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2539152
Product Specific Information
MA5-17767 targets I-Ap in CT and FACS applications and shows reactivity with Mouse samples.
The MA5-17767 immunogen is b10.p.
Target Information
MHC Class II (I-Ap) is a protein complex found on the surface of cells in vertebrates. Its main function is to present peptides derived from extracellular proteins to T cells for immune recognition. MHC Class II (I-Ap) is composed of an alpha and beta chain, both of which contribute to the peptide-binding groove. MHC Class II (I-Ap) is primarily restricted to antigen-presenting cells, including dendritic cells, macrophages, and B cells. These cells are responsible for capturing and processing antigens from the extracellular environment. Once the antigens are internalized, they are broken down into smaller peptides, which then bind to MHC Class II molecules within the endosomal compartments of these cells. MHC Class II (I-Ap) consists of an extracellular domain, a transmembrane domain, and a cytoplasmic tail. The extracellular domain is responsible for interacting with the antigenic peptides, while the transmembrane domain anchors the MHC Class II molecule to the cell membrane. The cytoplasmic tail plays a role in intracellular signaling events.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cell surface glycoprotein; H-2 class II histocompatibility antigen, I-E beta chain; I-E beta MHC class II; major histocompatibility complex H-2E beta chain; MHC class II IE-b; MHC H2-IE-beta cell surface glycoprotein
Gene Aliases: H-2Eb; H2Eb; Ia-4; Ia4
Entrez Gene ID: (Mouse) 14969
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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