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|Tested species reactivity||Mouse, Rat|
|Host / Isotype||Mouse / IgG2a, kappa|
|Immunogen||Mouse MHC class II, I-E subregion-encoded glycoprotein (I-Ek)|
|Storage buffer||proprietary buffer|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MHC class II molecules are heterodimers of non-covalently associated alpha (31-34 kDa) and beta (26-29 kDa) chains. Major histocompatibility complex class II antigen presentation requires the participation of lysosomal proteases in two convergent processes. First, the antigens endocytosed by the antigen presenting cells must be broken down into antigenic peptides. Second, class II molecules are synthesized with their peptide-binding site blocked by invariant chain (Ii), and they aquire the capacity to bind antigens only after Ii has been degraded in the compartments where peptides reside. MHC class II molecules present exogenously derived antigen to CD4+ T lymphocytes, which are usually T helper cells. CD4 interacts with non-polymorphic residues of MHC class II.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
cell surface glycoprotein; E-B beta chain; H-2 class II histocompatibility antigen; H-2 class II histocompatibility antigen, I-E beta chain; I-E beta MHC class II; major histocompatibility complex H-2E beta chain; MHC class II; MHC class II IE-b; MHC H2-IE-beta cell surface glycoprotein; MHC I-Ek
H-2Eb; H2Eb; Ia-4; Ia4