This antibody is predicted to react with mouse, rat, non-human primate and rabbit based on sequence homology.
Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Intercellular adhesion molecule-1 is a member of the immunoglobulin superfamily, and is critical for the adhesion and transmigration of leukocytes from blood vessels and into tissues. ICAM-1 is constitutively expressed on endothelial cells, but levels increase in response to proinflammatory cytokines. It is also expressed on smooth muscle cells, resulting in leukocyte accumulation, and activation of mononuclear cells. The expression of adhesion molecules on smooth muscle cells may be cell cycle-dependent, and influence smooth muscle cell proliferation and differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: BB2; CD54; cell surface glycoprotein P3.58; human rhinovirus receptor; ICAM-1; Intercellular adhesion molecule 1; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; Major group rhinovirus receptor; MALA-2; MyD10; P3.58
Gene Aliases: BB2; CD54; ICAM; Icam-1; ICAM1; Ly-47; MALA-2; P3.58