CD278 belongs to the CD28 and CTLA-4 cell-surface receptor family and is highly expressed in activated T-cells. It is essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. It enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: activation-inducible lymphocyte immunomediatory molecule; AILIM; CD278; CD28 and CTLA-4-like protein; CD28-related protein 1; CVID1; inducible costimulator; inducible T-cell co-stimulator; inducible T-cell costimulator
Gene Aliases: AILIM; CCLP; CD278; CRP-1; CVID1; H4; Ly115