M710B targets IFN alpha in ELISA applications and shows reactivity with Human samples.
The M710B immunogen is recombinant human IFN alpha 2b.
M710B detects IFN alpha which has a predicted molecular weight of approximately 19 kDa.
IFN alpha (Interferon alpha) is a Type I interferon belonging to a family of structurally related, species-specific proteins exclusive to vertebrates. The interaction of IFN-alpha with its receptor component result in the activation of a number of signaling pathways which are mainly involved in innate immune response against viral infection. In humans, the gene for IFN alpha is located on on chromosome 9. The type I interferons consist of 14 different alpha isoforms (subtypes with slightly different specificities), and single beta, omega, epsilon and kappa isoforms. Homologous molecules are found in many species, including rats and mice (and most mammals), and have been identified in birds, reptiles and fish species. IFN alpha is produced primarily by plasmacytoid dendritic cells, is a potent component of the anti-viral innate immune response and modulates adaptive immunity. Diseases associated with the dysfunction of IFN alpha include Hepatitis C and Hepatitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: IFN-alpha 1b; IFN-alpha-1/13; interferon alpha 1b; Interferon alpha-1/13; Interferon alpha-D; interferon, alpha 1; interferon-alpha1; LeIF D
Gene Aliases: IFL; IFN; IFN-ALPHA; IFN-alphaD; IFNA1; IFNA13; IFNA@
UniProt ID: (Human) P01562
Entrez Gene ID: (Human) 3439