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|Tested species reactivity||Human|
|Published species reactivity||Not Applicable|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Recombinant human interferon-alpha (IFN-alpha-A).|
|Storage buffer||PBS with 0.1% BSA|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Immunohistochemistry (IHC)||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Neutralization (Neu)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Interferon alpha (IFN alpha) is a Type I interferon belonging to a family of structurally related, species-specific proteins exclusive to vertebrates. The interaction of IFN-alpha with its receptor component results in the activation of a number of signaling pathways which are mainly involved in innate immune response against viral infection. In humans, the gene is located on on chromosome 9.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Improving the yield of soluble 6xHis-tagged interferon-alpha via the addition of repressor of the araBAD promoter system in Escherichia coli.
AHC4114 was used in western blot to report that alpha-D-glucopyranoside or D-fucose inhibits inclusion body formation in Escherichia coli
|Jung KH,Park YS,Yeon JH,Kim SH,Yoo SK,Jang BC||Biotechnology letters (30:1577)||2008|
Modulation of the tendency towards inclusion body formation of recombinant protein by the addition of glucose in the araBAD promoter system of Escherichia coli.
AHC4114 was used in western blot to try to modulate the overall protein expression rate through the addition of a repressor against the araBAD promoter system of Escherichia coli
|Lee YJ,Jung KH||Journal of microbiology and biotechnology (17:1898)||2007|
|Not Applicable||Not Cited||
Type I interferons are involved in the development of ultraviolet B-induced inflammatory skin lesions in systemic lupus erythaematosus patients.
AHC4114 was used in immunohistochemistry - paraffin section to study the involvement of type I interferons and endothelial cell adhesion molecules in the development of ultraviolet B-induced systemic lupus erythaematosus skin lesions
|Reefman E,Kuiper H,Limburg PC,Kallenberg CG,Bijl M||Annals of the rheumatic diseases (67:11)||2008|
|Not Applicable||Not Cited||
Stimulated plasmacytoid dendritic cells impair human T-cell development.
AHC4114 was used in flow cytometry to report that IFN-alpha inhibits the IL-7R signal transduction pathway
|Schmidlin H,Dontje W,Groot F,Ligthart SJ,Colantonio AD,Oud ME,Schilder-Tol EJ,Spaargaren M,Spits H,Uittenbogaart CH,Blom B||Blood (108:3792)||2006|
IFN-alpha 1b; IFN-alpha-1/13; interferon alpha 1b; Interferon alpha-1/13; Interferon alpha-D; interferon, alpha 1; interferon-alpha1; LeIF D
IFL; IFN; IFN-ALPHA; IFN-alphaD; IFNA1; IFNA13; IFNA@