|ELISA (ELISA)||Assay Dependent|
|Immunohistochemistry (IHC)||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Neutralization (Neu)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
|ELISA (ELISA)||See 1 publications below|
|Tested Species reactivity||Human|
|Published species reactivity||Virus Human|
|Host / Isotype||Sheep / Ig|
|Immunogen||Recombinant human interferon-beta (Hu-IFN-beta) produced in E. coli.|
|Storage buffer||whole serum diluted in PBS|
Type I Interferons (IFN-alpha/beta) are produced primarily in response to viral infection by "Natural IFN-producing cells" (IPCs) as part of the host immune response and can also inhibit the development of tumors. IFN-beta binding by its receptor results in the activation of the tyrosine kinases Jak1 and Tyk2 and phosphorylation of members of the STAT family of transcription factors, leading to the transcription and expression of the immune response genes. More recently, several members of the toll-like receptor (TLR) family were found to stimulate the production IFN-beta. IFN-beta is currently used clinically for treatment of tumors, infections and multiple sclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Fibroblast interferon; IFN-beta; Interferon beta; interferon, beta 1, fibroblast; interferon-beta; Rat interferon Beta IFNB
Gene Aliases: IFB; IFF; IFN-beta; IFNB; IFNB1
UniProt ID: (Human) P01574
Entrez Gene ID: (Human) 3456
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