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|Tested species reactivity||Pig|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG2a, kappa|
|Immunogen||Recombinant porcine IFN gamma|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Blocking Assay (BLOCK)||See 1 publications below|
MP701 targets IFN gamma in WB and ELISA applications and shows reactivity with Porcine samples.
The MP701 immunogen is recombinant porcine IFN gamma.
MP701 detects IFN gamma which has a predicted molecular weight of approximately 17 kDa.
IFN gamma, also called Type II interferon, macrophage activation factor, and immune interferon is produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, Staphylococcus enterotoxin B, phytohemaglutanin and other cytokines. IFN gamma is a glycoprotein that exists, functionally, as a homodimer of approximately 45 kDa. On SDS-PAGE it appears as a combination of 25, 20 and minor 15.5 kDa bands as a result of differential glycosylation. The biological activity of the IFN gamma homodimer is highly species specific and includes the following: antiviral activity, tumor antiproliferative activity, induction of class I and II MHC, macrophage activation, and enhanced immunoglobulin secretion by B lymphocytes. IFNg is involved in cytokine regulation and also acts synergistically with other cytokines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Enhanced antiviral activity against foot-and-mouth disease virus by a combination of type I and II porcine interferons.
MP701 was used in blocking/activating experiment to study the antiviral effects of interferons in pigs
|Moraes MP,de Los Santos T,Koster M,Turecek T,Wang H,Andreyev VG,Grubman MJ||Journal of virology (81:7124)||2007|