|Flow Cytometry (Flow)||Assay Dependent|
|Miscellaneous PubMed (MISC)||See 2 publications below|
|Tested Species reactivity||Human|
|Published species reactivity||Human Rhesus monkey|
|Host / Isotype||Mouse / IgG1, kappa|
APC-Alexa Fluor® 750
|Excitation/Emission Profile||View spectra|
|Storage buffer||PBS with BSA|
|Contains||0.1% sodium azide|
|Storage conditions||4° C|
IFN gamma, also called Type II interferon, macrophage activation factor, and immune interferon is produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, Staphylococcus enterotoxin B, phytohemaglutanin and other cytokines. IFN gamma is a glycoprotein that exists, functionally, as a homodimer of approximately 45 kDa. On SDS-PAGE it appears as a combination of 25, 20 and minor 15.5 kDa bands as a result of differential glycosylation. The biological activity of the IFN gamma homodimer is highly species specific and includes the following: antiviral activity, tumor antiproliferative activity, induction of class I and II MHC, macrophage activation, and enhanced immunoglobulin secretion by B lymphocytes. IFNg is involved in cytokine regulation and also acts synergistically with other cytokines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: IFN-gamma; IFN-y; IFNG; Immune interferon; Interferon gamma; Interferon y; interferon, gamma
Gene Aliases: IFG; IFI; IFNG
UniProt ID: (Human) P01579
Entrez Gene ID: (Human) 3458
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