Description: Anti-human IFN-omega (OMG-2) neutralize the antiviral activity of IFN-omega.
In the human genome, the IFN-omega gene family consists of seven members located on chromosome 9. However, only one of these genes is functional giving rise to the IFN-omega protein, whereas the others are non-functional pseudogenes. The IFN-omega gene is not expressed in unstimulated cells. Viral infection results in expression of the gene giving rise to the N-glycosylated protein consisting of 172 or 174 amino acids and an apparent molecular mass of about 25kDa. A single carbohydrate group consists mainly of biantennary complex oligosaccharides with variable amounts of N-acetyl neuraminic acid. In quantitative terms, IFN-omega is a major component of human leukocyte IFN; with a contribution to its total antiviral activity estimated to be in the range of 10 -15 %.
Applications Tested: ELISA.
The protein encoded by this gene is produced by macrophages and has antiviral activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: IFN-omega 1, interferon omega-1; Interferon alpha-II-1; Interferon omega-1; interferon, omega 1
Gene Aliases: IFNW1
UniProt ID: (Human) P05000
Entrez Gene ID: (Human) 3467