Proteintech

IFT88 Monoclonal Antibody (4A4G5)

IFT88 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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IFT88 Antibody (60227-1-IG) in IHC (P)

Immunohistochemistry of paraffin-embedded human pancreas using 60227-1-Ig (IFT88 antibody) at dilution of 1:50 (under 40x lens).

IFT88 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

60227-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

4A4G5

Immunogen

IFT88 Fusion Protein Ag4980 (532-833 aa encoded by BC030776)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody was raised against the C-terminal region of human IFT88 and can detect the endogenous level of IFT88.

Immunogen sequence: NIGLTYEKL NRLDEALDCF LKLHAILRNS AEVLYQIANI YELMENPSQA IEWLMQVVSV IPTDPQVLSK LGELYDRGGD KSQAFQYYYE SYRYFPCNIE VIEWLGAYYI DTQFWEKAIQ YFERASLIQP TQVKWQLMVA SCFRRSGNYQ KALDTYKDTH RKFPENVECL RFLVRLCTDL GLKDAQEYAR KLKRLEKMKE IREQRIKSGR DGSGGSRGKR EGSASGDSGQ NYSASSKGER LSARLRALPG TNEPYESSSN KEIDASYVDP LGPQIERPKT AAKKRIDEDD FADEELGDDL LPE (532-833 aa encoded by BC030776)

Target Information

This gene encodes a member of the tetratrico peptide repeat family. Mutations of a similar gene in mouse can cause polycystic kidney disease. Two transcript variants encoding distinct isoforms have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

2-IPMA Ameliorates PM2.5-Induced Inflammation by Promoting Primary Ciliogenesis in RPE Cells.

Molecules (Basel, Switzerland)

Choi JY,Bae JE,Kim JB,Jo DS,Park NY,Kim YH,Lee HJ,Kim SH,Kim SH,Jeon HB,Na HW,Choi H,Ryu HY,Ryoo ZY,Lee HS,Cho DH

Mon Sep 06 00:00:00 UTC 2021

Microtubule Stabilization Enhances the Chondrogenesis of Synovial Mesenchymal Stem Cells.

Frontiers in cell and developmental biology

Li J,Sun Z,Lv Z,Jiang H,Liu A,Wang M,Tan G,Guo H,Sun H,Wu R,Xu X,Yan W,Jiang Q,Ikegawa S,Shi D

Wed Nov 10 00:00:00 UTC 2021

Crosstalk between the COX2-PGE2-EP4 signaling pathway and primary cilia in osteoblasts after mechanical stimulation.

Journal of cellular physiology

Li YH,Zhu D,Yang T,Cheng L,Sun J,Tan L

Tue Jun 01 00:00:00 UTC 2021

Ttc39c is upregulated during skeletal muscle atrophy and modulates ERK1/2 MAP kinase and hedgehog signaling.

Journal of cellular physiology

Hayes CS,Labuzan SA,Menke JA,Haddock AN,Waddell DS

Sun Dec 01 00:00:00 UTC 2019

Chibby functions to preserve normal ciliary morphology through the regulation of intraflagellar transport in airway ciliated cells.

Cell cycle (Georgetown, Tex.)

Siller SS,Burke MC,Li FQ,Takemaru K

Tue Aug 30 00:00:00 UTC 2016

Chibby functions to preserve normal ciliary morphology through the regulation of intraflagellar transport in airway ciliated cells.

Cell cycle (Georgetown, Tex.)

Siller SS,Burke MC,Li FQ,Takemaru K

Tue Aug 30 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: HGNC:20606; intraflagellar transport 88 homolog; Intraflagellar transport protein 88 homolog; MGC26259; polaris homolog; probe hTg737 (polycystic kidney disease, autosomal recessive); Recessive polycystic kidney disease protein Tg737; Recessive polycystic kidney disease protein Tg737 homolog; RP11-172H24.2; testicular tissue protein Li 93; tetratricopeptide repeat domain 10; Tetratricopeptide repeat protein 10; Tg737 protein; TgN(Imorpk)737Rpw; TPR repeat protein 10; transgene insert site 737, insertional mutation, polycystic kidney disease

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Gene Aliases: AW552028; D13S1056E; DAF19; flexo; fxo; hTg737; IFT88; orpk; polaris; TG737; Tg737Rpw; TgN737Rpw; TTC10

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UniProt ID: (Human) Q13099, (Mouse) Q61371

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Entrez Gene ID: (Human) 8100, (Mouse) 21821, (Rat) 305918

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Function(s)

protein binding kinesin binding

Process(es)

cilium morphogenesis regulation of cilium assembly regulation of autophagosome assembly eye development kidney development liver development epithelial cell morphogenesis Notch signaling pathway smoothened signaling pathway sperm axoneme assembly spermatid nucleus elongation determination of left/right symmetry nervous system development brain development heart development protein localization epidermis development regulation of smoothened signaling pathway organ morphogenesis anterior/posterior pattern specification dorsal/ventral pattern formation spinal cord dorsal/ventral patterning telencephalon development cell projection organization lung development pancreas development cytoplasmic microtubule organization response to fluid shear stress nonmotile primary cilium assembly epidermal stem cell homeostasis cilium assembly regulation of odontogenesis of dentin-containing tooth embryonic digit morphogenesis positive regulation of insulin-like growth factor receptor signaling pathway regulation of fat cell differentiation forebrain morphogenesis negative regulation of epithelial cell proliferation cardiac muscle cell differentiation palate development inner ear receptor stereocilium organization limb development regulation of feeding behavior cardiac septum morphogenesis lung vasculature development heart formation neural precursor cell proliferation regulation of protein processing cochlea development

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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IFT88 Monoclonal Antibody (4A4G5)

IFT88 Antibody (60227-1-IG) in IHC (P)

Product Details

60227-1-IG

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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