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|Tested species reactivity||Human|
|Published species reactivity||Mouse|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Purified human placental IGF-1 receptors.|
|Storage buffer||PBS, pH 7.4|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1-10 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|ChIP assay (ChIP)||See 1 publications below|
MA1-10854 detects IGF-1 Receptor from human samples.
MA1-10854 has been successfully used in Western blot applications. Dilute in PBS or medium which is identical to that used in the assay system.
The MA1-10854 immunogen is purified human placental IGF-1 receptors.
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Differential activation of a C/EBP beta isoform by a novel redox switch may confer the lipopolysaccharide-inducible expression of interleukin-6 gene.
MA1-10854 was used in chimmunoprecipitation to investigate the relationship between the transcriptional activities of different C/EBP beta isoforms and the regulation of interleukin 6 gene expression
|Su WC,Chou HY,Chang CJ,Lee YM,Chen WH,Huang KH,Lee MY,Lee SC||The Journal of biological chemistry (278:51150)||2003|
CD221; IGF-I receptor; IGFIR; IGFR; insulin-like growth factor I receptor; JTK13; soluble IGF1R variant 1; soluble IGF1R variant 2
CD221; IGF1R; IGFIR; IGFR; JTK13