|Tested species reactivity||Human|
|Published species reactivity||Mouse|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Purified human placental IGF-I receptor|
|Storage buffer||PBS, pH 7.4|
|Contains||0.09% sodium azide|
|Storage Conditions||4°C or -20°C if preferred|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1/10|
|Immunohistochemistry (Paraffin) (IHC (P))||1:10-1:40|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|ChIP assay (ChIP)||See 1 publications below|
This product requires protein digestion pre-treatment of paraffin sections using trypsin or pronase. A suggested positive control for immunohistochemical applications is pancreas or placenta. For FACS analysis, use 10ul of the suggested working dilution to label 1x10^6 cells in 100ul.
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Differential activation of a C/EBP beta isoform by a novel redox switch may confer the lipopolysaccharide-inducible expression of interleukin-6 gene.
MA1-81548 was used in chimmunoprecipitation to investigate the relationship between the transcriptional activities of different C/EBP beta isoforms and the regulation of interleukin 6 gene expression
|Su WC,Chou HY,Chang CJ,Lee YM,Chen WH,Huang KH,Lee MY,Lee SC||The Journal of biological chemistry (278:51150)||2003|