|Tested species reactivity||Human, Rat|
|Published species reactivity||Rat|
|Host / Isotype||Mouse / IgG2b, kappa|
|Immunogen||A 15-mer peptide corresponding to aa 1323-1337 (Tyr-RKNERALPLPQSSTC) from the C-terminal of beta-subunit of human IGF-1R|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Western Blot (WB)||1-2 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 1 publications below|
MA5-13822 targets IGF-1 Receptor beta in WB applications and shows reactivity with Human and Rat samples.
The MA5-13822 immunogen is a 15-mer peptide corresponding to aa 1323-1337 (Tyr-RKNERALPLPQSSTC) from the C-terminal of beta-subunit of human IGF-1R.
IGF-1R consists of alpha- and beta-subunits, which are disulfide-linked in a beta-alpha-alpha-beta configuration in the mature receptor. The alpha-subunit is completely extracellular, while the beta-subunit spans the membrane and the intracellular portion has intrinsic tyrosine kinase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
An IGF-I antagonist does not inhibit renal fibrosis in the rat following subtotal nephrectomy.
MA5-13822 was used in western blot to study the effect of an IGF-1 antagonist on renal fibrosis in the rat
|Oldroyd SD,Miyamoto Y,Moir A,Johnson TS,El Nahas AM,Haylor JL||American journal of physiology. Renal physiology (290:F695)||2006|