Immunohistochemical analysis of paraffin-embedded human gastric adenocarcinoma (A), colon adenocarcinoma (B), endometrial carcinoma (uterus) (C), ovary adenocarcinoma (D), lung squamous cell carcinoma (E), stomach epithelium mucosae (F) using CD221/IGF1 Receptor beta monoclonal antibody (Product # MA5-15343) followed with DAB staining.
|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG2b|
|Immunogen||Purified recombinant fragment of IGF1R-Beta expressed in E. Coli.|
|Contains||0.03% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (IHC)||1/200 - 1/1000|
|Western Blot (WB)||1/500 - 1/2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-15343 targets IGF1R in IHC and WB applications and shows reactivity with Human samples.
The MA5-15343 immunogen is purified recombinant fragment of IGF1R-Beta expressed in E. Coli.
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.