|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide from CYR61 (Human)|
|Storage buffer||PBS, pH 7.2, with 1% BSA, 50% glycerol|
|Contains||0.02% sodium azide|
|Storage Conditions||-80° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1-4 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-23143 detects CYR61 in Human, Mouse and Rat samples.
PA1-23143 has been successfully used in Western Blot procedures.
PA1-23143 immunogen corresponds to Synthetic peptide from CYR61 (Human).
CYR61 is a secreted, cysteine-rich, heparin-binding protein encoded by a growth factor inducible immediate-early gene. It promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion and appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA A, VEGA C, MMP1, MMP3, TIMP1, uPA, PAI 1 and integrins alpha 3 and alpha 5. Cyr61 mediated gene regulation is dependent on heparin binding. Down-regulates the expression of alpha-1 and alpha 2 subunits of collagen type 1. Promotes cell adhesion and adhesive signaling through integrin alpha 6/beta 1, cell migration through integrin alpha v/beta 5 and cell proliferation through integrin alpha v/beta 3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.