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Immunohistochemical analysis of paraffin-embedded human colon carcinoma (A), breast carcinoma (B), kidney cell carcinoma (C), bladder carcinoma tumor (D), showing membrane and cytoplasmic localization using IKBKB monoclonal antibody (Product # MA5-15320) followed with DAB staining.
|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Purified recombinant fragment of IKBKB expressed in E. Coli.|
|Contains||0.03% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (IHC)||1/200 - 1/1000|
|Western Blot (WB)||1/500 - 1/2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-15320 targets IKBKB in IHC and WB applications and shows reactivity with Human samples.
The MA5-15320 immunogen is purified recombinant fragment of IKBKB expressed in E. Coli.
NFKB1 or NFKB2 is bound to REL to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime .
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
I-kappa-B kinase 2; I-kappa-B-kinase beta; IKBKB; IKK-B; nuclear factor NF-kappa-B inhibitor kinase beta
IKBKB; IKK-beta; IKK2; IKKB; IMD15; NFKBIKB