Inhibitor of Nuclear factor Kappa-B kinase subunit alpha (IKK alpha) is encoded by the CHUK gene and located on chromosome 10 in humans. It is also known as IKK1 or CHUK (Conserved helix-loop-helix ubiquitous kinase). IKK alpha belongs to the family of serine threonine protein kinase and forms a part of IKK complex. The IKK complex is required for the activation of NF-kB with IKK alpha specifically known to be involved in the non-canocial pathway for NF-kB activation. IKK alpha along with IKK beta and a regulatory protein NEMO (IKK gamma) phosphorylates IkB proteins which targets the later for ubiquitin mediated degradation. It is involved with several cellular processes with extensive studies on its role in inflammation and cell survival.
Protein Aliases: Conserved helix-loop-helix ubiquitous kinase; EC 126.96.36.199; FLJ40509; I kappa B kinase 1; I-kappa-B kinase 1; I-kappa-B kinase alpha; I-kappa-B kinase-alpha; ikappaB kinase; IkappaB kinase alpha; IkB kinase alpha subunit; IKBKB; IKK alpha; IKK-A; IKK-a kinase; IKK-B; IKK-beta; IKK1; IKKB; Inhibitor of nuclear factor kappa-B kinase subunit alpha; kinase beta; MGC131801; NFKBIKA; Nuclear factor NF-kappa-B inhibitor kinase alpha; Nuclear factor NFkappaB inhibitor kinase alpha; TCF-16; Transcription factor 16
Gene Aliases: AI256658; CHUK; Chuk1; Fbx24; Fbxo24; IKBKA; IKK-alpha; IKK1; IKKA; NFKBIKA; TCF16
UniProt ID: (Human) O15111