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Product Details
MA5-15691
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
3G12
Immunogen
Purified recombinant fragment of human CHUK expressed in E. Coli.
Conjugate
Unconjugated
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
AB_10985543
Product Specific Information
MA5-15691 targets CHUK in indirect ELISA, WB applications and shows reactivity with Human samples.
The MA5-15691 immunogen is purified recombinant fragment of human CHUK expressed in E. Coli.
MA5-15691 detects CHUK which has a predicted molecular weight of approximately 85kDa.
Target Information
Inhibitor of Nuclear factor Kappa-B kinase subunit alpha (IKK alpha) is encoded by the CHUK gene and located on chromosome 10 in humans. It is also known as IKK1 or CHUK (Conserved helix-loop-helix ubiquitous kinase). IKK alpha belongs to the family of serine threonine protein kinase and forms a part of IKK complex. The IKK complex is required for the activation of NF-kB with IKK alpha specifically known to be involved in the non-canocial pathway for NF-kB activation. IKK alpha along with IKK beta and a regulatory protein NEMO (IKK gamma) phosphorylates IkB proteins which targets the later for ubiquitin mediated degradation. It is involved with several cellular processes with extensive studies on its role in inflammation and cell survival.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Conserved helix-loop-helix ubiquitous kinase; EC 2.7.11.10; FLJ40509; I-kappa-B kinase 1; I-kappa-B kinase alpha; I-kappa-B kinase-alpha; ikappaB kinase; IkB kinase alpha subunit; IKBKB; IKK-a kinase; IKK-B; IKK-beta; IKK1; IKKB; Inhibitor of nuclear factor kappa-B kinase subunit alpha; kinase beta; MGC131801; NFKBIKA; Nuclear factor NF-kappa-B inhibitor kinase alpha; Nuclear factor NFkappaB inhibitor kinase alpha; TCF-16; Transcription factor 16
Gene Aliases: CHUK; IKBKA; IKK-alpha; IKK1; IKKA; NFKBIKA; TCF16
UniProt ID: (Human) O15111
Entrez Gene ID: (Human) 1147
Molecular Function:
non-receptor serine/threonine protein kinase
protein modifying enzyme
stimulatory C-type lectin receptor signaling pathway
skeletal muscle contraction
protein phosphorylation
inflammatory response
immune response
I-kappaB kinase/NF-kappaB signaling
I-kappaB phosphorylation
Rho protein signal transduction
response to virus
response to toxic substance
anatomical structure morphogenesis
response to acetate
regulation of tumor necrosis factor-mediated signaling pathway
response to lipopolysaccharide
response to hydroperoxide
TRIF-dependent toll-like receptor signaling pathway
NIK/NF-kappaB signaling
Fc-epsilon receptor signaling pathway
response to drug
positive regulation of I-kappaB kinase/NF-kappaB signaling
response to amino acid
innate immune response
positive regulation of transcription from RNA polymerase II promoter
T cell receptor signaling pathway
positive regulation of NF-kappaB transcription factor activity
striated muscle cell differentiation
stress-activated MAPK cascade
nucleotide-binding oligomerization domain containing signaling pathway
cellular response to tumor necrosis factor
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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