PA1-4162 detects IKK gamma in human samples. This antibody recognizes both human IKK gamma isoforms.
PA1-4162 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~50 kDa protein representing the IKK gamma protein in Interleukin-1-stimulated 293 cells.
The PA1-4162 immunogen is a synthetic peptide corresponding to residues R(385) R S P P E E P P D F C C P K(399) of human IKK gamma.
Pro-inflammatory cytokines activate the transcription factor NF-kappaB by stimulating the activity of a protein kinase that phosphorylates IkappaB, an inhibitor of NF-kappaB, at sites that trigger its ubiquitination and degradation. A large, cytokine-responsive IkappaB kinase (IKK) complex contains 2 subunits, IKK-alpha and IKK-beta, which are protein kinases whose function is needed for NF-kappaB activation by pro-inflammatory stimuli. IKK is composed of similar amounts of IKK-alpha, IKK-beta, which are differentially processed forms of a third subunit, IKK-gamma. IKK-gamma interacts preferentially with IKK-beta and is required for the activation of the IKK complex.
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Protein Aliases: FIP-3; I-kappa-B kinase subunit gamma; IkB kinase gamma subuni; ikB kinase subunit gamma; IkB kinase-associated protein 1; IKKAP1; incontinentia pigmenti; Inhibitor of nuclear factor kappa-B kinase gamma subunit; Inhibitor of nuclear factor kappa-B kinase subunit gamma; NEMO; NF-kappa-B essential modifier; NF-kappa-B essential modulator
Gene Aliases: AMCBX1; FIP-3; FIP3; Fip3p; IKBKG; IKK-gamma; IKKAP1; IKKG; IMD33; IP; IP1; IP2; IPD2; NEMO; ZC2HC9
UniProt ID: (Human) Q7LBY6
Entrez Gene ID: (Human) 8517