PA5-27335 targets IKK gamma in IHC (P) and WB applications and shows reactivity with Human and mouse samples.
The PA5-27335 immunogen is recombinant fragment corresponding to a region within amino acids 4 and 199 of Human IKK gamma.
This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome.
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Protein Aliases: AMCBX1; FIP-3; FIP3; Fip3p; I-kappa-B kinase subunit gamma; IkB kinase gamma subunit; ikB kinase subunit gamma; IkB kinase-associated protein 1; IKK-gamma; IKKAP1; IKKG; incontinentia pigmenti; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; inhibitor of nucl; Inhibitor of nuclear factor kappa-B kinase subunit gamma; IP1; IP2; IPD2; mFIP-3; NEMO; NF-kappa-B essential modifier; NF-kappa-B essential modulator; NFkappaB essential modulator
Gene Aliases: 1110037D23Rik; AI848108; AI851264; AMCBX1; AW124339; FIP-3; FIP3; Fip3p; IKBKG; IKK-gamma; IKK[g]; IKKAP1; IKKG; IMD33; IP; IP1; IP2; IPD2; NEMO; ZC2HC9