Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Pro-inflammatory cytokines activate the transcription factor NF-kappaB by stimulating the activity of a protein kinase that phosphorylates IkappaB, an inhibitor of NF-kappaB, at sites that trigger its ubiquitination and degradation. A large, cytokine-responsive IkappaB kinase (IKK) complex contains 2 subunits, IKK-alpha and IKK-beta, which are protein kinases whose function is needed for NF-kappaB activation by pro-inflammatory stimuli. IKK is composed of similar amounts of IKK-alpha, IKK-beta, which are differentially processed forms of a third subunit, IKK-gamma. IKK-gamma interacts preferentially with IKK-beta and is required for the activation of the IKK complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: I-kappa-B kinase gamma; I-kappa-B kinase subunit gamma; ikB kinase subunit gamma; ikB kinase-associated protein 1; IKK-gamma; IKKAP1; IKKG; incontinentia pigmenti; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; inhibitor of kappaB kinase gamma; inhibitor of nuclear factor kappa-B kinase subunit gamma; mFIP-3; NF-kappa B essential modulator; NF-kappa-B essential modifier; NF-kappa-B essential modulator
Gene Aliases: 1110037D23Rik; AI848108; AI851264; AMCBX1; AW124339; FIP-3; FIP3; Fip3p; IKK-gamma; IKK[g]; IKKAP1; IKKG; IMD33; IP; IP1; IP2; IPD2; NEMO; ZC2HC9