|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Recombinant human IL-1 alpha|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|ELISA (ELISA)||See 1 publications below|
M420A targets IL-1 alpha in ELISA applications and shows reactivity with Human samples.
The M420A immunogen is recombinant human IL-1 alpha.
M420A detects IL-1 alpha which has a predicted molecular weight of approximately 18 kDa.
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Prostaglandin E2 induces the final maturation of IL-12-deficient CD1a+CD83+ dendritic cells: the levels of IL-12 are determined during the final dendritic cell maturation and are resistant to further modulation.
M420A was used in ELISA to investigate the roles of prostaglandin E2 and interleukin 10 in CD1a+ dendritic cell maturation
|Kali¿ski P,Schuitemaker JH,Hilkens CM,Kapsenberg ML||Journal of immunology (Baltimore, Md. : 1950) (161:2804)||1998|