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Mouse thiogylcolate-induced peritoneal exudate cells (PECs) were stimulated with LPS in the presence of Brefeldin A for 22 hours. The cells were surface stained with Anti-Mouse CD11b PE and then intracellularly stained with Rat IgG2b kappa Isotype Control FITC (top) or Anti-Mouse IL-1 alpha FITC (bottom, A18463).
|Tested species reactivity||Mouse|
|Host / Isotype||Hamster / IgG|
|Immunogen||mouse interleukin-1 alpha|
|Storage buffer||proprietary buffer|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
IL-1 alpha, interleukin-1 alpha, hematopoietin-1, preinterleukin 1 alpha, pro-interleukin-1-alpha, IL1A