|Tested species reactivity||Human|
|Published species reactivity||Human, Mouse|
|Host / Isotype||Mouse / IgG1, kappa|
|Clone||508A4A2 and 508A7G8|
|Immunogen||Recombinant human IL-1b|
|Storage buffer||PBS, pH 7.5|
|Contains||0.05% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|ELISA (ELISA)||See 3 publications below|
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Caspase activity is required for stimulated B lymphocytes to enter the cell cycle.
AHC0612 was used in ELISA to study how caspase-6 regulates the cell cycle of tonsillar B cells.
|Olson NE,Graves JD,Shu GL,Ryan EJ,Clark EA||Journal of immunology (Baltimore, Md. : 1950) (170:6065)||2003|
Igf-I inhibits spontaneous apoptosis in human granulocytes.
AHC0612 was used in ELISA to examine the effects of IGF-I on in vitro apoptosis of human peripheral blood granulocytes.
|Kooijman R,Coppens A,Hooghe-Peters E||Endocrinology (143:1206)||2002|
|Mouse||Not Cited||Biological characterization of lipopolysaccharide from Treponema pectinovorum.||Kesavalu L,Falk CW,Davis KJ,Steffen MJ,Xu X,Holt SC,Ebersole JL||Infection and immunity (70:211)||2002|