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|Tested species reactivity||Chicken|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant Chicken IL-1|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Functional Assay (FN)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-84913 nuetralizes chicken IL-1 beta.
In Western blot, this antibody detects a band at ~29kDa in HD-11 cell lysates transfected with chIL-1.
IL-1 is a major regulator in both innate and adaptive immune responses. It plays an important role in regulation of acute inflammation and has also been implicated in many other processes, including both fever and fibrinogen induction. The previous names by which IL-1 has been known includes lymphocyte activating factor, endogenous pyrogen, catabolin, hemopoietin-1, melanoma growth inhibition factor, and osteoclast activating factor, reflecting its widespread cell expressio. Studies using chicken models have indicated physiological similarities between chIL-1 beta and mammalian IL-1 beta in relation to its neural distribution and several factors have been shown to induce chIL-1 beta secretion, including protein kinase C (PKC), Calmodulin-dependent protein kinase, lipopolysaccharide, phorbol esters, calcium and silica.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.