|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Purified recombinant human IL-10.|
|Storage buffer||PBS, pH 7.5|
|Contains||0.05% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (IHC)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Interleukin 10 (IL-10) is an anti-inflammatory cytokine mainly produced by macrophages and Th2 cells. IL-10 functions by inhibiting pro-inflammatory cytokines made by macrophages and regulatory T cells including, IFN-gamma, TNF-alpha, IL-2, and IL-3, IL-4, and GM-CSF. IL-10 is also known to suppress antigen presentation on antigen presenting cells. While human IL-10 can act on murine cells, murine IL-10 cannot act on human cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Local immunosuppression induced by high viral load of human papillomavirus: characterization of cellular phenotypes producing interleukin-10 in cervical neoplastic lesions.
AHC9102 was used in immunohistochemistry (paraffin) to elucidate the role of IL-10 in human papillomavirus infection.
|Prata TT,Bonin CM,Ferreira AM,Padovani CT,Fernandes CE,Machado AP,Tozetti IA||Immunology (146:113)||2015|
Psoriasis is characterized by deficient negative immune regulation compared to transient delayed-type hypersensitivity reactions.
AHC9102 was used in immunohistochemistry - frozen section to investigate factors that regulate delayed-type hypersensitivity
|Gulati N,Suárez-Fariñas M,Correa da Rosa J,Krueger JG||F1000Research (4:null)||2015|
Differential effects of endurance training and weight loss on plasma adiponectin multimers and adipose tissue macrophages in younger, moderately overweight men.
AHC9102 was used in immunohistochemistry - paraffin section to determine the effects of endurance training-induced weight loss, diet-induced weight loss, and endurance training per se (without weight loss) on plasma adiponectin and adipose tissue macrophage content in young, moderately overweight men.
|Auerbach P,Nordby P,Bendtsen LQ,Mehlsen JL,Basnet SK,Vestergaard H,Ploug T,Stallknecht B||American journal of physiology. Regulatory, integrative and comparative physiology (305:R490)||2013|
||Localized immunosuppression in the cardiac allograft induced by a new liposome-mediated IL-10 gene therapy.||Hong YS,Laks H,Cui G,Chong T,Sen L||The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation (21:1188)||2002|
|Human||Not Cited||Localized immunosuppression in the cardiac allograft induced by a new liposome-mediated IL-10 gene therapy.||Hong YS,Laks H,Cui G,Chong T,Sen L||The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation (21:1188)||2002|
|Human||Not Cited||In situ expression of cytokines in human heart allografts.||Van Hoffen E,Van Wichen D,Stuij I,De Jonge N,Klöpping C,Lahpor J,Van Den Tweel J,Gmelig-Meyling F,De Weger R||The American journal of pathology (149:1991)||1996|