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|Tested species reactivity||Pig|
|Published species reactivity||Pig, Rat, Hamster, Not Applicable|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Recombinant swine IL-10.|
|Storage buffer||PBS, pH 7.2|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Interleukin 10 (IL-10) is an anti-inflammatory cytokine mainly produced by macrophages and Th2 cells. IL-10 functions by inhibiting pro-inflammatory cytokines made by macrophages and regulatory T cells including, IFN-gamma, TNF-alpha, IL-2, and IL-3, IL-4, and GM-CSF. IL-10 is also known to suppress antigen presentation on antigen presenting cells. While human IL-10 can act on murine cells, murine IL-10 cannot act on human cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
A novel DNA vaccine for reduction of PRRSV-induced negative immunomodulatory effects: A proof of concept.
ASC0104 was used in immunocytochemistry to discuss the role of nucleocapsid-induced IL-10 production and generation of PRRSV-specific Tregs.
|Suradhat S,Wongyanin P,Kesdangsakonwut S,Teankum K,Lumyai M,Triyarach S,Thanawongnuwech R||Vaccine (33:3997)||2015|
Negative impact of porcine reproductive and respiratory syndrome virus infection on the efficacy of classical swine fever vaccine.
ASC0104 was used in flow cytometry to examine the effect of porcine reproductive and respiratory syndrome virus infection on classical swine fever vaccine efficacy.
|Suradhat S,Kesdangsakonwut S,Sada W,Buranapraditkun S,Wongsawang S,Thanawongnuwech R||Vaccine (24:2634)||2006|
Cytokine profiles in pregnant gilts experimentally infected with porcine reproductive and respiratory syndrome virus and relationships with viral load and fetal outcome.
ASC0104 was used in ELISA to compare host cytokine responses between porcine reproductive and respiratory syndrome virus-infected and non-infected pregnant gilts.
|Ladinig A,Lunney JK,Souza CJ,Ashley C,Plastow G,Harding JC||Veterinary research (45:null)||2014|
|Immune response characteristics following emergency vaccination of pigs against foot-and-mouth disease.||Barnard AL,Arriens A,Cox S,Barnett P,Kristensen B,Summerfield A,McCullough KC||Vaccine (23:1037)||2005|
|Not Applicable||Not Cited||
Effects of porcine reproductive and respiratory syndrome virus-infected antigen-presenting cells on T cell activation and antiviral cytokine production.
ASC0104 was used in blocking or activating experiment to show that porcine reproductive and respiratory syndrome virus can suppress T cells
|Charerntantanakul W,Platt R,Roth JA||Viral immunology (19:646)||2007|
|Not Applicable||Not Cited||
The kinetics of cytokine production and CD25 expression by porcine lymphocyte subpopulations following exposure to classical swine fever virus (CSFV).
ASC0104 was used in flow cytometry to report the kinetics of IFN-gamma and interleukin-10 production relative to CD25 expression in porcine lymphocyte subpopulations after immunization with a classical swine fever vaccine
|Suradhat S,Sada W,Buranapraditkun S,Damrongwatanapokin S||Veterinary immunology and immunopathology (106:197)||2005|