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|Tested species reactivity||Human|
|Published species reactivity||Rat, Non-human primate, Human, Mouse|
|Host / Isotype||Rat / IgG1, kappa|
|Immunogen||Recombinant human Interleukin 10.|
|Storage buffer||PBS, pH 7.2|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Flow Cytometry (Flow)||Assay Dependent|
|Neutralization (Neu)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|ELISA (ELISA)||See 3 publications below|
Interleukin 10 (IL-10) is an anti-inflammatory cytokine mainly produced by macrophages and Th2 cells. IL-10 functions by inhibiting pro-inflammatory cytokines made by macrophages and regulatory T cells including, IFN-gamma, TNF-alpha, IL-2, and IL-3, IL-4, and GM-CSF. IL-10 is also known to suppress antigen presentation on antigen presenting cells. While human IL-10 can act on murine cells, murine IL-10 cannot act on human cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Non-human primate||Not Cited||Multiplex analysis of cytokines in the blood of cynomolgus macaques naturally infected with Ebola virus (Reston serotype).||Hutchinson KL,Villinger F,Miranda ME,Ksiazek TG,Peters CJ,Rollin PE||Journal of medical virology (65:561)||2001|
|Human||Not Cited||Cytokine responses to treponema pectinovorum and treponema denticola in human gingival fibroblasts.||Nixon CS,Steffen MJ,Ebersole JL||Infection and immunity (68:5284)||2000|
|Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples.||Abrams JS,Roncarolo MG,Yssel H,Andersson U,Gleich GJ,Silver JE||Immunological reviews (127:5)||1992|
CSIF; Cytokine synthesis inhibitory factor; IL-10; IL10A; Interleukin-10; MGC126450; MGC126451; T-cell growth inhibitory factor; TGIF
CSIF; GVHDS; IL-10; IL10; IL10A; TGIF