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|Tested species reactivity||Human|
|Published species reactivity||Primate|
|Host / Isotype||Rat / IgG1, kappa|
|Immunogen||Recombinant human Interleukin 10.|
|Storage buffer||PBS, pH 7.2|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Flow Cytometry (Flow)||Assay Dependent|
|Neutralization (Neu)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|ELISA (ELISA)||See 1 publications below|
Interleukin 10 (IL-10) is an anti-inflammatory cytokine mainly produced by macrophages and Th2 cells. IL-10 functions by inhibiting pro-inflammatory cytokines made by macrophages and regulatory T cells including, IFN-gamma, TNF-alpha, IL-2, and IL-3, IL-4, and GM-CSF. IL-10 is also known to suppress antigen presentation on antigen presenting cells. While human IL-10 can act on murine cells, murine IL-10 cannot act on human cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Multiplex analysis of cytokines in the blood of cynomolgus macaques naturally infected with Ebola virus (Reston serotype).
||Hutchinson KL,Villinger F,Miranda ME,Ksiazek TG,Peters CJ,Rollin PE||Journal of medical virology (65:561)||2001|
T-cell growth inhibitory factor, cytokine synthesis inhibitory factor, interleukin-10, CSIF, IL10A, MGC126450, MGC126451, TGIF, Interleukin-10
RP11-262N9.1, CSIF, TGIF, GVHDS, IL10A, IL-10
Signal transduction Cell surface receptor mediated signal transduction Cytokine and chemokine mediated signaling pathway Cell communication Ligand-mediated signaling Immunity and defense Macrophage-mediated immunity Cytokine/chemokine mediated immunity Apoptosis Inhibition of apoptosis Cell proliferation and differentiation